The Carcinolytic Action of Sera *

نویسندگان

  • George H. Smith
  • Elizabeth F. Jordan
  • Florence B. Mack
چکیده

The early years of the present century witnessed the publication of a great many papers, stimulated by the work and by the theories of Bordet and Metchnikoff, dealing with the production and mode of action of cytolytic and cytotoxic sera. To the cells of very diverse mammalian tissues specific antisera exhibiting lytic action, or activities so interpreted, were produced and upon the basis of inference many theories were developed concerning a variety of pathologic conditions. Experience has shown, however, that little of practical value has resulted from the demonstration of antibodies of this type, if the hemolysin, which is of such wide application as an indicator in serologic technic, be exduded. Until recently but little further attention has been paid to antibodies of this character, although from time to time attempts have been made to find in such serological methods a means for detecting malignancy. Freund and Kaminer, Lehmann-Facius, Neuberg, and Lumsden have all developed technics involving basically the cytolytic or cytotoxic principle. Some of these methods make use of native sera, others develop antisera by artificial immunization, but all are directed toward demonstrating an effect of the serum upon carcinoma cells or on a derivative of these cells. The renewed activity along these lines has been attended by an intensive search for possible specific antigenic components in cancer tissue, and, indeed, such have been found, with further proof that such antigens can serve for inducing specific reacting-bodies under experimental conditions. However, despite all demonstrations of this kind none of the serological reactions based upon earlier technical methods has proved to be even moderately satisfactory when applied to diagnostic ends. Thus it is that the reaction described by Lehmann-Facius, the so-called carcinolytic action, might seem to offer possibilities not only of development into a practical laboratory technic, but also for determining certain facts with regard to the relationship of carcinoma to diverse serological changes. Examination of the papers of Lehmann-Facius would suggest that from the technical standpoint the distinguishing feature of such tests

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Carcinolytic Action and Erythrocyte Sedimentation *

During a study of the behavior of sera derived from patients with carcinoma it became obvious that with the so-called "carcinolytic reaction" consistent results were not to be obtained, although accumulating data but added to the conviction that such sera possess properties which, in their action on cancer cells, distinguish them from normal sera. Inability so to adjust a carcinoma cell-serumco...

متن کامل

Reticuloendothelial Immune Serum (REIS)

The importance of the reticuloendothelial system in relation to neoplasms has been recently brought into focus by a group of Soviet workers. According to Shimkin (18), blockading of the reticuloendothelial system has been used by Roskin (16) as a means of growing heteroplastic tumors. Bogomolets (3) has reported the effect of specific antireticular cytotoxic serum (ACS) on the genesis, survival...

متن کامل

Effect of the Sera of Patients with Multiple Sclerosis on Apoptosis and Nitric Oxide Production of Endothelial Cells

Background & Aims: Multiple sclerosis (MS) is one of the chronic autoimmune diseases of the central nervous system with unknown etiology. The present study aimed to investigate the apoptosis and nitric oxide (NO) production of endothelial cells treated with serum of patients with MS and response to interferon beta (IFN- ) therapy. Methods: Human umbilical vein endothelial cells were treated wit...

متن کامل

Umbelliprenin induced both anti-inflammatory and regulatory cytokines in C57/BL6 mice

Objective(s): Umbelliprenin is a prenyloxy-coumarin with pharmacologically polyvalent activity. Several studies have shown its anti-inflammatory, anti-tumor, antioxidant, and antigenotoxic activity, and other functions. However, the exact mechanism of action of this compound on the immune response has not yet been shown. Here, we investigated umbelliprenin effects on the predominance of Th1 and...

متن کامل

The development and biochemical characterization of resistance to azaserine in a TA 3 ascites carcinoma.

The development of resistance in neoplastia cells to carcinostatic or carcinolytic agents is con sidered one of the most important factors limiting the success of cancer chemotherapy. At present the mechanisms of drug resistance are, for the most part, unknown or controversial. A knowledge of the biochemical changes responsible for the mani festation of resistance should permit greater ra tiona...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • The Yale Journal of Biology and Medicine

دوره 8  شماره 

صفحات  -

تاریخ انتشار 1936